Thank you visiting EP forum, the skin can't not automatically resize itself for different screen resolutions.
But you can use seperate images on MainWindow and anchor them so that they will appear at the right positions. These images should be large enough in width or height so that they will always be seen. See this example http://www.easypano.com/gallery/tourweaver600/cruise/tour.html
You can download the original project of the above tour to have a better understanding : http://www.easypano.com/gallery/tourweaver600/cruise-project.zip
This is donald from easypano,welcome you to use our products and visit our forum.